Antonio Margarito (right) and Ramon Alvarez at the weigh-in prior to their 12-round junior middleweight bout on Saturday, Aug. 13, 2016. Photo credit: German Villasenor

It is difficult for many fighters to hang up the gloves for good.

Antonio Margarito is another of a long list of fighters who believe they have one more run at a big money fight or a world title belt.

That is nothing out of the ordinary but Margarito is a shadow of the fighter he was eight-to-10 years ago. Not to mention his right eye has been a cause for concern, considering the amount of damage it has sustained in his bouts against Manny Pacquiao and Miguel Cotto.

Is Margarito risking further damage to his eye when he returns to the ring Saturday night?

That could be the case when he faces Ramon Alvarez in a 12-round junior middleweight bout at the Centro de Convenciones in Rosarito, Baja California, Mexico.

The bout will air live on beIN Sports Espanol, beginning at 11 p.m. ET/8 p.m. PT.

Margarito (39-8, 27 knockouts) announced his retirement from the ring after his knockout loss to Miguel Cotto in December of 2011. While the 38-year-old stated he retired from boxing to spend time with his family, it was also due to the extensive damage in and around his right eye.

The damage to his eye first occurred in the Pacquiao fight in November of 2010, in which Margarito suffered a fractured orbital bone below the eye and damage to his right retina.

Margarito underwent multiple procedures to his retina and the orbital bone and required further procedures after the Cotto fight as well.

Margarito returned to the the ring on March 5, over four years removed from the Cotto fight. He won a close 10-round unanimous decision over Jorge Paez Jr. but was knocked down in the sixth round.

With the recent news of Israel Vazquez likely losing his right eye due to the amount of damage from tough fights he suffered, how many more fights would Margarito realistically fight? How long would commissions allow him to compete?

Juan Carlos Pelayo, director of the Tijuana Boxing Commission, told ESPN Deportes, “We will not have anything extraordinary other than the routine tests.”

“In his last fight, one of the requirements of his return was to take part in a very rigorous study that was done by an ophthalmologist of a high prestige and he passed. So there shouldn’t be any problem.”

Ramon Alvarez (23-4-2, 15 KOs), an older brother of RING middleweight champion Canelo Alvarez, is unbeaten in his last 10 bouts (which includes a no contest).

Alvarez has notable wins over Omar Chavez, Vivian Harris and Ben Tackie.

Opening the beIN Sports Espanol broadcast will be a 10-round junior featherweight bout between Edivaldo Ortega (24-0-1, 11 KOs) and Emanuel Navarrete (14-1, 13 KOs).

Junior welterweight prospect Pedro Campa (21-0, 16 KOs) will face David Bency (10-5-1, 4 KOs) in a 10 round bout.